The Neuropixels Probe: A CMOS Based Integrated Microsystems Platform for Neuroscience and Brain-Computer Interfaces
International Electron Devices Meeting(2019)
Abstract
We review recent progress in neural probes for brain recording, with a focus on the Neuropixels platform. Historically the number of neurons’ recorded simultaneously, follows a Moore’s law like behavior, with numbers doubling every 6.7 years. Using traditional techniques of probe fabrication, continuing to scale up electrode densities is very challenging. We describe a custom CMOS process technology that enables electrode counts well beyond 1000 electrodes; with the aim to characterize large neural populations with single neuron spatial precision and millisecond timing resolution. This required integrating analog and digital circuitry with the electrode array, making it a standalone integrated electrophysiology recording system. Input referred noise and power per channel is 7.5µV and <50µW respectively to ensure tissue heating <1°C. This approach enables doubling the number of measured neurons every 12 months.
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Key words
tissue heating,CMOS based integrated microsystems platform,integrated electrophysiology recording system,electrode array,digital circuitry,millisecond timing resolution,single neuron spatial precision,neural populations,electrode counts,electrode densities,Moore's law,brain recording,neural probes,brain-computer interfaces,neuroscience,Neuropixels probe
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