Dynamic protein interfaces and conformational landscapes of membrane protein complexes
Current Opinion in Structural Biology(2020)
摘要
•Dynamic membrane protein interfaces, in particular in GPCRs suggest novel regulatory and organizational paradigms.•Long timescale atomistic simulations give a glimpse of interactions between disordered binding regions.•Coarse-grain simulations are able to capture multiple binding modes of protein-protein interfaces.•Integrative coarse-grain and atomistic simulations with enhanced sampling techniques are the way forward.
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