An Institutional Series Of Early-Onset Pancreatic Cancer (Eopc): Clinical Outcomes And Genetic And Supportive Care Referral Patterns

652 Background: The incidence of EOPC is rising and is associated with substantial implications for affected individuals and their families. Little is known about the extent of physician referrals of these patients (pts) to genetic, supportive care, and hospice services. Methods: Pts with EOPC (≤50 years) were identified using the institutional tumor registry for years 2011-2018 and retrospectively reviewed. Clinical data and rates of referral to supportive, genetic and hospice services were retrieved. Descriptive analyses were performed with 25-75% interquartile ranges (IQR) where appropriate. Overall survival (OS) was assessed using Kaplan-Meier curves and Cox Proportional Hazards modeling. Results: In total, 113 pts with EOPC and a median age of 47 years (range, 28-50) were analyzed. Of these 113 pts, 43% were female, 27% were black, and 45% had metastatic disease at initial presentation. The most commonly administered first line chemotherapy was FOLFIRINOX, with gemcitabine/nab-paclitaxel reserved for the second line. The median OS of pts with metastatic disease was 5.8 compared to 15.8 months for those without metastases. Only 28% of pts were referred to genetic services, and 72% of these underwent genetic testing. Out of the genetically tested pts, pathogenic germline mutations were confirmed for 33%. Of the original 113 pts, 41% received concurrent palliative care, which was provided at a median of 2.4 mos. (IQR, 0.7-6.8) preceding death. The median time between last chemotherapy administered and death was 2 mos. (IQR, 1-4.4), with 23% receiving treatment within the last month of life. Only 55% used hospice services prior to death for a median duration of 0.5 mos. (IQR, 0.2-1.4). Conclusions: Our study suggests that there is a tendency for late utilization of supportive and hospice care in pts with EOPC, possibly due to the desire of both pts and physicians to be more aggressive given the young age. Larger studies are warranted to elucidate barriers to concurrent supportive care, and whether formation of specialized young patient supportive care clinics would aid this situation and to avoid the use of unnecessary chemotherapy near the end of life.