A Phase Ib Study Of Troriluzole (Bhv-4157) In Combination With Nivolumab

Ann W. Silk,Biren Saraiya,Roman Groisberg,Nancy Chan,Kristen Renee Spencer,Eugenia Girda,Weichung Shih, Veeraswamy Manne,Marisa Palmeri,Robert Berman,Vlad Coric,Joshua Vieth,Suzie Chen,Janice M. Mehnert,Jyoti Malhotra

JOURNAL OF CLINICAL ONCOLOGY（2020）

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79Background: The Metabotropic Glutamate Receptor 1 (GRM1) is overexpressed in many solid tumors. It activates MAPK and PI3K/AKT pathways and promotes an immune-suppressive tumor microenvironment. ...

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