Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation.

Ming-Hua Hsu,Cheng-Ying Hsieh,Mohit Kapoor, Jui-Hsun Chang,Hsueh-Liang Chu,Tsai-Mu Cheng,Kai-Cheng Hsu,Tony Eight Lin,Fu-Yuan Tsai,Jia-Cherng Horng

Bioorganic Chemistry（2020）

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摘要

•A series of leucettamine B analogs are quickly synthesized by microwave-assisted heating.•Two of our synthesized compounds show the potent inhibition of various cancer cell lines.•One of our synthesized compounds is predicted to relate with several protein targets such as CLK1, CLK3, IKKB and DYRK2.

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关键词

Leucettamine B,Barbituric acid,Thiazolidinone,Carborane

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