Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro.
Microbial Pathogenesis(2020)
Abstract
•MiR-147b expression was higher and cell viability decreased in H32Rv-THP-1 cells.•Cell viability was shown higher after miR-147b downregulation.•RT-qPCR found C11orf87 expression was lower in the H32Rv-THP-1 cells.•Moreover, when H32Rv-THP-1 cells were co-transfected with miR-147b inhibitor and si-C11orf87, cell viability, migration and EMT.•Activation of Pi3K/AKT pathway was partially reversed compared with mere downregulation of miR-147b.
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Key words
Tuberculosis,MicroRNA147b,Cell viability,Macrophage,C11orf87
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