Inhibition Of Protein Disulfide Isomerase Has Neuroprotective Effects In A Mouse Model Of Experimental Autoimmune Encephalomyelitis

M. H. Harirchian,M. Kamarehei,S. Pejman,S. Kaboudanian Ardestani,H. Zahednasab,M. Firouzi

MULTIPLE SCLEROSIS JOURNAL（2020）

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摘要

•CCF642 inhibited PDI enzyme effectively in the hippocampus of EAE mice.•CCF642 ameliorated EAE clinical symptoms by PDI inhibition and reduction of ER stress-related neuroinflammation.•CCF642 decreased apoptosis associated with caspase-12 and CHOP in the hippocampus of EAE mice.

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关键词

Endoplasmic reticulum stress,Neuroinflammation,Protein disulfide isomerase,Experimental autoimmune encephalomyelitis,CCF642

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