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The impact of sitagliptin on macrophage polarity and angiogenesis in the osteointegration of titanium implants in type 2 diabetes.

Geng Xiang,Xinyi Huang,Tianji Wang, Jing Wang, Guoxuan Zhao,Han Wang,Yafei Feng,Wei Lei,Xiaofan Hu

Biomedicine & Pharmacotherapy（2020）

Cited 18|Views12
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Abstract
•Diabetes causes macrophage polarization imbalance, worsening endothelial injury.•Sitagliptin attenuates endothelial damage in DM by repolarizing M2 macrophage.•Sitagliptin regulated M1/M2 polarization, improving angiogenesis and osteogenesis.
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Key words
Angiogenesis,Diabetes,Macrophage polarization,Sitagliptin,Titanium implants
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