Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4 / NF-κB / NLRP3 signaling in mice.
Brain Research(2020)
摘要
•PTEN, TLR4, NF-κB and NLRP3 are increased in the hippocampus of PSD mice.•PTEN suppression downregulates TLR4, NF-κB and NLRP3 in PSD mouse hippocampus.•Exercise ameliorates PSD via PTEN/TLR4/NF-κB/NLRP3 signaling.
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关键词
exercise,depression,tlr4/nf-κb/nlrp3,post-stroke,elevation-mediated
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