IL-18 immunoadjuvanted xenogeneic canine MMP-7 DNA vaccine overcomes immune tolerance and supresses the growth of murine mammary tumor

Pavan Kumar Yadav, Shishir Kumar Gupta,Saroj Kumar,Mayukh Ghosh,Brijesh Singh Yadav,Dinesh Kumar,Ajay Kumar,Mohini Saini,Meena Kataria

International Immunopharmacology（2020）

引用 6|浏览12

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摘要

•Proteolysis of ECM and basement membrane by MMP-7 promotes tumorigenic invasion.•pVIVO.cMMP-7.IL-18 DNA vaccine elicits strong cellular immune response in Balb/c mice.•The xenovaccine overcomes immunological tolerance.•It exerts a potent anti-tumor response in the murine breast cancer model.

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关键词

Anti-tumor immune response,Mammary tumor,Matrix metealloproteinase-7,Xenogeneic DNA vaccine

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