Risk factors related to hepatic injury in patients with corona virus disease 2019
medRxiv(2020)
摘要
Aims: Corona virus disease 2019 (COVID-19) has rapidly become the most severe
public health issue all over the world. Despite respiratory symptoms, hepatic injury
has also been observed in clinical settings. This study aimed to investigate the risk
factors involved with hepatic injury in the patients with COVID-19.
Methods: A total of 85 hospitalized patients who were diagnosed with COVID-19 in
Beijing You’an Hospital were retrospectively analyzed. According to liver function,
they were divided into ALT normal group (n=52) and ALT elevation group (n=33).
Clinical features and laboratory data were compared between the two groups. The
independent risk factors for liver injury were analyzed.
Results: There were 33 patients with hepatic injury in our study, accounting for 38.8%
(33/85). The patients in ALT elevation group were older than those in ALT normal
group. The levels of lactic acid, CRP, myoglobin, and neutrophils were significantly
higher in ALT elevation group. The lymphocytes and albumin were significantly
lower in ALT elevation group. The proportion of severe and critical patients in ALT
elevation group was significantly higher. Multivariate logistic regression analysis
showed CRP ≥20 mg/L and lymphocyte count< 1.1×10^9/L were independently
related to hepatic injury.
Conclusions: Lymphopenia and CRP may serve as the risk factors related to hepatic
injury in patients with COVID-19, which might be related to inflammatory cytokine
storm in liver injury. Early detection and timely treatment of hepatic injury in patients
with COVID-19 are necessary.
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关键词
COVID-19,hepatic injury,lymphopenia,C reactive protein
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