NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus
European Biophysics Journal(2020)
摘要
Elongation factor P (EF-P) is a translation protein factor that plays an important role in specialized translation of consecutive proline amino acid motifs. EF-P is an essential protein for cell fitness in native environmental conditions. It regulates synthesis of proteins involved in bacterial motility, environmental adaptation and bacterial virulence, thus making EF-P a potential drug target. In the present study, we determined the solution and crystal structure of EF-P from the pathogenic bacteria Staphylococcus aureus at 1.48 Å resolution. The structure can serve as a platform for structure-based drug design of novel antibiotics to combat the growing antibiotic resistance of S. aureus .
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关键词
Ribosome,
Staphylococcus aureus
, EF-P, NMR, Protein structure, X-ray, Drug target
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