Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir.

Julie Copelyn,Jeffrey R Hincks,Jo M Wilmshurst,Wonita Petersen,Wayne Howard,Sabelle Jallow,Shelina Moonsamy,Lerato Seakamela,Melinda Suchard,Marc S Collett,Brian Eley

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2020）

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摘要

Pocapavir exhibits antiviral activity against both polio and nonpolio enteroviruses. There is limited experience of the use of this investigational drug in young children with enteroviral infection. We describe the successful clearance of prolonged immunodeficiency-associated vaccine-derived type 3 poliovirus infection by pocapavir in an infant with underlying X-linked agammaglobulinemia.

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关键词

pocapavir,immunodeficiency-associated vaccine-derived poliovirus,poliovirus,primary immunodeficiency

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