Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21.

Koh Nakamaru,Takashi Tomiyama,Sanshiro Kobayashi,Manami Ikemune,Satoshi Tsukuda,Takashi Ito,Toshihiro Tanaka,Takashi Yamaguchi,Yugo Ando,Tsukasa Ikeura,Toshiro Fukui,Akiyoshi Nishio,Makoto Takaoka,Kazushige Uchida,Patrick S C Leung,M E Gershwin,Kazuichi Okazaki

Pancreatology（2020）

引用 13|浏览94

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摘要

Circulating EVs exhibited altered miRNA expression patterns with elevated miR-21-5p in AIP when compared with those in HC and CP. miR-21-5p was highly expressed in pancreatic inflammatory cells in AIP. Our data suggests that miR-21-5p may be involved in the regulation of effector pathways in the pathophysiology of AIP, thus differentiating AIP from CP.

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关键词

Microarray,RT-PCR,In situ hybridization,Inflammatory cell

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