Topical application of high dose mesna prevents adhesion formation: an experimental animal study

G. Arslan,M. Berkesoglu,Y. Y. Karabulut,D. Derici Yildirim,O. M. Turkmenoglu,M. M. Dirlik

VIRCHOWS ARCHIV（2020）

Cited 5|Views10

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Abstract

This is the first study for mesna on prevention of abdominal adhesion formation in rats. We concluded that dose-dependent reduction of adhesion was achieved by mesna. With future studies, topical administration of mesna during open abdominal surgeries may be used to prevent adhesion formation.

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Key words

2-Mercaptoethanesulfonate,Abdomen,Laparotomy,Mesna,Surgical adhesions,Uromitexan

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