6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis

•6-Deoxyjacareubin suppressed hypoxia-induced cell death via non-apoptotic pathway.•Early 6-deoxyjacareubin administration prolonged survival time in familial ALS model.•6-Deoxyjacareubin attenuates motor neuron loss and glial activation.•6-Deoxyjacareubin may be a therapeutic strategy for hypoxia-related neurodegeneration.