The on-off action of Forkhead protein O3a in endotoxin tolerance of Kupffer cells depends on the PI3K/AKT pathway.

Di Mu,Chunmu Miao,Yao Cheng,Peizhi Li,Jianping Gong,Wenfeng Zhang

International Immunopharmacology（2020）

引用 3|浏览17

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摘要

•Foxo3a in the nucleus is closely related to KCs tolerance of LPS.•Overexpression of Foxo3a improves KCs ET by inhibiting of NF-κB.•Suppression of PI3K/AKT improves the KCs and mice ET by increasing Foxo3a expression.

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关键词

Endotoxin tolerance,Kupffer cells,Fork head protein O3a,Nuclear factor kappa B,Phosphatidylinositol-3-hydroxykinase

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