Dynamics of structural reversal in Bruch’s membrane opening-based morphometrics after glaucoma drainage device surgery
Graefe's Archive for Clinical and Experimental Ophthalmology(2020)
Abstract
Purpose Structural reversal of disc cupping is a known phenomenon after trabeculectomy. The aim of this retrospective, longitudinal, cross-sectional analysis was to evaluate the postoperative dynamics of Bruch’s membrane opening-based morphometrics of the optic nerve head following glaucoma drainage device surgery. Methods Forty-three eyes, treated by glaucoma drainage device surgery, were included in the study. Individual changes in the spectral domain optic coherence tomography (SD-OCT) parameters Bruch’s membrane opening minimum rim width (BMO-MRW), Bruch’s membrane opening minimum rim area (BMO-MRA) and peripapillary retinal nerve fiber layer (RNFL) thickness as well as mean defect in 30–2 perimetry were analyzed. Changes were correlated to postoperative intraocular pressure levels over time. Available follow-up visits were aggregated and grouped into a short-term follow-up (20 to 180 days after surgery), a midterm follow-up (181 to 360 days after surgery) and a long-term follow-up (more than 360 days after surgery). Results In short-term follow-up, BMO-MRW and BMO-MRA increased significantly ( p <= 0.034). This increase correlated negatively with the intraocular pressure at the time of the follow-up (Pearson’s rho = − 0.49; p = 0.039). From 6 months after surgery on, there was no statistically significant change in BMO-MRW and BMO-MRA ( p >= 0.207). RNFL thickness and mean defect of 30–2 perimetry showed no significant changes after GDD implantation ( p >= 0.189). Conclusions Lowering of intraocular pressure by glaucoma drainage device surgery leads to an increase of Bruch’s membrane opening based parameters in the first 6 months after surgery. These changes have to be taken into account when evaluating patients’ longitudinal follow-up after glaucoma drainage device implantation.
MoreTranslated text
Key words
Glaucoma, Optic nerve head, Glaucoma drainage device surgery, Optic coherence tomography
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined