Managing Depressive Symptoms In People With Mild Cognitive Impairment And Mild Dementia With A Multicomponent Psychotherapy Intervention: A Randomized Controlled Trial

Objective:To evaluate the feasibility and effectiveness of the CORDIAL program, a psychosocial intervention consisting of cognitive behavioral therapy (CBT), cognitive rehabilitation, and reminiscence to manage depressive symptoms for people with mild cognitive impairment (MCI) or dementia.Design:We conducted a randomized controlled trial, based on a two-group (intervention and control), pre-/post-intervention design.Setting:Participants were recruited from five different old age psychiatry and memory clinics at outpatients' hospitals.Participants:Hundred and ninety-eight people with MCI or early-stage dementia were included.Intervention:The intervention group (n = 100) received 11 individual weekly sessions of the CORDIAL program. This intervention includes elements from CBT, cognitive rehabilitation, and reminiscence therapy. The control group (n = 98) received treatment-as-usual.Measurements:We assessed Montgomery-angstrom sberg Depression Rating Scale (MADRS) (main outcome), Neuropsychiatric Inventory Questionnaire, and Quality of Life in Alzheimer's disease (secondary outcomes) over the course of 4 months and at a 10-month follow-up visit.Results:A linear mixed model demonstrated that the depressive symptoms assessed by MADRS were significantly more reduced in the intervention groups as compared to the control group (p < 0.001). The effect persisted for 6 months after the intervention. No significant differences between groups were found in neuropsychiatric symptoms or quality of life.Conclusion:Our multicomponent intervention, which comprised 11 individual sessions of CBT, cognitive rehabilitation, and reminiscence therapy, reduced depressive symptoms in people with MCI and dementia.