Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions.
ORGANIC LETTERS(2020)
摘要
A catalyst-, oxidant-, electrolyte-free method for the preparation of alpha-ketoamides through the direct electrochemical amidation of alpha-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry.
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关键词
electrochemical synthesis,electrolyte-free
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