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Engineering human knock-in organoids

Qiutan Yang,Koen C. Oost,Prisca Liberali

NATURE CELL BIOLOGY（2020）

Cited 6|Views15
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Abstract
The lack of endogenous reporter lines is a bottleneck in the study of subcellular dynamics in human adult stem cell (ASC)-derived organoids. An approach using CRISPR–Cas9-mediated homology-independent organoid transgenesis (CRISPR–HOT) in ASC-derived organoids now narrows the gap between basic research and translational studies in human organoids.
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Key words
CRISPR-Cas9 genome editing,Cellular imaging,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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