Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning.

Kahleb D Graham,Silvia Huerta López,Rajarshi Sengupta,Archana Shenoy,Sabine Schneider,Christina M Wright,Michael Feldman,Emma Furth,Federico Valdivieso, Amanda Lemke,Benjamin J Wilkins,Ali Naji, Edward Doolin,Marthe J Howard,Robert O Heuckeroth

Gastroenterology（2020）

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摘要

We developed a 3-dimensional imaging method for colon that provides more information about ENS structure than tissue sectioning. This approach could improve diagnosis for human bowel motility disorders and may be useful for other bowel diseases.

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关键词

Myenteric Plexus,Submucosal Ganglia,Nitric Oxide,Acetylcholine,Hirschsprung Disease

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