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Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease

Julien Caliez,Marianne Riou,Gregoire Manaud,Morad K. Nakhleh,Marceau Quatredeniers,Catherine Rucker-Martin,Peter Dorfmuller,Florence Lecerf, Maria C. Vinhas,Salam Khatib, Hossam Haick,Sylvia Cohen-Kaminsky, Marc Humbert,David Montani,Frederic Perros

PULMONARY CIRCULATION（2020）

Cited 4|Views52
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Abstract
Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.
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Key words
trichloroethylene,pulmonary veno-occlusive disease,endothelial permeability
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