Preliminary in vitro Evaluation of a Semisynthetic Oestrogen Polymer-based Formulation

Oestrogen hormones play key roles in the human body, are involved in complex mechanisms, both beneficial and unwanted. Because semisynthetic oestrogens are commonly used today in various hormonal therapies, they has inevitably been linked to the appearance of certain carcinogenic processes, which are primarily based on oestrogen-based drugs, either as initiators or promoters. A promising alternative that can help reduce unwanted effects is to capture the active substance in a polymeric matrix that is capable of retaining its biological activity. In this study, activity on the viability of breast cancer cells with expressed oestrogen receptors of a polymeric formulation with ethinylestradiol and polylactic acid was evaluated.