Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report

A. Romero,L. Midaglia, M.T. Salcedo, L. Viladomiu, E. Guillén, I. Bajaña,L. Escolà-Vergé,M. Tintoré,X. Montalban,O. Len

Multiple Sclerosis and Related Disorders(2020)

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摘要
•Alemtuzumab is used for treating relapsing-remitting multiple sclerosis.•Alemtuzumab produces a prolonged lymphocyte depletion with deferred t cell reconstitution.•This late repopulation of t cells favors the risk of autoimmune diseases.•Hemophagocytic syndrome could be one of this adverse events.•Hemophagocytic syndrome can lead to a severe progressive multi-organ failure.
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关键词
Multiple sclerosis,Alemtuzumab,Hemophagocytic syndrome,Adverse effects,Autoimmune disease,Corticosteroids
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