A sulfated polysaccharide from the edible flesh of Cipangopaludina chinensis inhibits angiogenesis to enhance atherosclerotic plaque stability

Qingping Xiong,Hailun Li,Li Zhou,Jian Liang, Ziyun Zhang,Yun Han,Yi Jing,Youdong Hu,Yingying Shi,Tingting Xu, Guoqing Qian,Jun Yuan

Journal of Functional Foods（2020）

Cited 8|Views11

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Abstract

•Sulphated polysaccharide (CCPSs) from Cipangopaludina chinensis can stabilize plaque.•CCPSs can significantly reduce vulnerability index of atherosclerotic plaques.•CCPSs can significantly inhibit angiogenesis in atherosclerotic plaques.•Inhibitory role of CCPSs on angiogenesis was regulated by PI3K/Akt/mTOR pathway.

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Key words

Sulfated polysaccharides,Cipangopaludina chinensis,Stability of atherosclerotic plaque,Angiogenesis

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