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Hepatoprotective effect of pyrroloquinoline quinone against alcoholic liver injury through activating Nrf2-mediated antioxidant and inhibiting TLR4-mediated inflammation responses

Xiaoxia Jiang,Yafeng Zhou,Yun Zhang,Diying Tian,Su Jiang,Yunping Tang

Process Biochemistry（2020）

Cited 16|Views5
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Abstract
•PQQ alleviates acute alcoholic liver injury in mice.•PQQ against acute alcoholic liver injury by activating Nrf2-mediated signaling in vivo.•PQQ against acute alcoholic liver injury by inhibiting TLR4/NF-κB signaling in vivo.
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Key words
Pyrroloquinoline quinone,Alcoholic liver injury,Oxidative stress,Nrf2 signal pathway,NF-κB signal pathway
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