Therapeutic Strategies for Corneal Wound Angiogenesis

Purpose of Review Corneal diseases are a major cause of blindness worldwide, resulting from corneal scarring and neovascularization. There is an unmet need for developing effective therapies to prevent and/or treat corneal neovascularization. Recent Findings Topical steroid medication, cautery, argon and yellow dye laser, and fine needle diathermy have all been advocated with varying degrees of success. Vascular endothelial growth factor family of proteins play a pivotal role in corneal neovascularization, and current therapies are aimed at disrupting the various steps in this pathway. Advancement in cell-based therapies and regulatory molecules as a therapeutic target for treating corneal neovascularization is gaining popularity. Summary This review focuses on the current treatment modalities, new alternative therapies, potential new targets, and insights into the future research for this debilitating condition.