Innovation and strategic orientations for the development of advanced biorefineries

•Advanced biorefineries are seen as key to implement a sustainable biobased economy.•Total valorization of biomass can boost the industrial implementation of biorefineries.•Tailor-made enzymes may increase process performance, reducing loadings and costs.•Big Data Analytics will enable better decision-making in biorefineries.•Interdisciplinary collaboration efforts are essential to develop sustainable biorefineries.