One nanometer self-assembled aptamer-DNA dendrimers carry 350 doxorubicin: Super-stability and intra-nuclear DNA comet tail

Jingqing Le, Jianguo Xu, Junxia Zheng, Bifei Li, Tingting Zheng, Yusheng Lu, Weiyu Shen, Anna V. Kudryavtseva, Vladimir L. Katanaev, Jingwei Shao, Lee Jia

Chemical Engineering Journal（2020）

引用 10|浏览23

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摘要

•The DNA dendrimers display super-stability in serum after annealing.•The sgc8-DNA dendrimers show specific binding to target cells in blood.•The sgc8-DNA dendrimers-Dox specifically induce DNA damage of the target cells evidenced by the comet tail, and can trace the target cells in mice.

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关键词

Self-assembly,DNA dendrimer,Comet tail,Doxorubicin,Theranostics

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