Antimicrobial production by strictly anaerobic Clostridium spp.

•Antimicrobial discovery has been biased towards aerobes and facultative anaerobes.•Obligate anaerobes such as Clostridium spp. have been overlooked.•Genomic studies have shown the potential of strict anaerobes to produce bioactive compounds, including antimicrobials.•Limited studies conducted so far have identified the genus Clostridium as a viable source of antimicrobial compounds.•Genomic approaches with culture-based methods may allow identification of novel antimicrobial classes from Clostridium spp.