Pengaruh suhu penyimpanan terhadap stabilitas klindamisin fosfat dalam sediaan emulgel dengan hydroxypropyl methylcellulose (hpmc) sebagai gelling agent

The present study was undertaken to investigate the effect of temperature on the degradation of clindamycin phosphate emulgel. This study aims to determine the rate of decomposition of clindamycin phosphate emulgel was storage at three different temperature of 30˚C, 50˚C, and 70˚C. Determination of percentage clindamycin phosphate was carried out every hour for 5 hours using Spectrophotometry UV-VIS. The results were statistically analyzed using the paired t-test. It was found a decrease in the levels of clindamycin phosphate emulgel at the storage temperature of 30˚C by 99.0874; 50˚C by 96.9314%, and a storage temperature of 70˚C by 96.0114%. Therefore, it can be said that clindamycin phosphate in emulgel preparations is chemically stable for 5 hours at a storage temperature of 30˚C, 50˚C, and 70˚C and the kinetics of the degradation rate of clindamycin phosphate in the emulgel preparation is in accordance with the second-order. Based on the statistically processed data result, it can be concluded that the storage temperature of 30˚C, 50˚C, and 70˚C shows that there is a significant difference (<0.005) in the data.