P-0055 Clinical Features and Treatment of Gastric Gist - our Experience

Abstract Introduction GIST is the most common mesenchymal tumor of the gastrointestinal tract. GISTs can occur anywhere along the GI tract, but are most common in the stomach (39-70%). Objective: To present 15 cases with gastric GIST treated surgically at our institution during 2005-2011. Methods A prospective analysis of clinical and pathologic features, age, sex, tumor location, size, surgical methods, mitotic index, immuno-chemistry an mid-term follow up were evaluated in 16 patients with gastric GIST. Results The patientu0027s age range was 38-73 years (mean 57.6 years), 9 male and 6 female patients (ratio 1.3:1). Tumor was found in gastric corpus 5, antrum 4 and antro-corporal part 3 and cardia 3 cases. Exogastric growth was observed in 11 patients while an endogastric pattern was seen in 4. The tumor size was from 4 to 16.5 cm. Ulcerations were present in 12 (80%) patients. Following surgical procedures were performed; wedge resection in 7 cases, subtotal gastrectomy in 6 cases and emergency total gastrectomy in 2 cases. In 11 patients were found less than 5 whereas in four patients more than 5 mitotic cells. The immunochemistry was more positive in CD117 and CD34. A mid-term follow-up (3 to 48 months) after surgery shows that all patients were disease free and no recurrence was detected. Conclusion The prevalence of gastric GIST, a very rare entity in the past, is increasing in our department. Upper GI endoscopy indicated by gastrointestinal bleeding and CT scan were the main preoperative diagnostic tools. Mid-term follow-up showed that wedge resection of the stomach was an adequate and effective surgical procedure in the majority of cases.