DNA Nanotechnology on Live Cell Membranes

Recent developments in DNA nanotechnology have brought various nanoscale structures, devices and functional systems for different applications. As biological barriers with significant functions, cell membranes provide direct interfaces for studying cellular environment and states. So far, DNA nanotechnology engineered on live cell membranes has advanced our fundamental understandings of DNA nanomaterials and facilitated the designs of novel sensing, imaging and therapeutic platforms. In this review, we highlighted strategies and outcomes of using DNA nanotechnology on cell membranes towards various biomedical applications, including biosensing, imaging, cellular function regulations and targeted cancer therapy. Furthermore, we also discussed the challenges and opportunities of DNA nanotechnology on cell membranes towards broader applications.