Is colistin-associated acute kidney injury clinically important in adults? A systematic review and meta-analysis

•Colistin was associated with an ~2-fold higher incidence of acute kidney injury (AKI) than other antibiotics.•Colistin-associated AKI was usually mild and reversible without higher rates of mortality or renal replacement therapy.•Colistin combined with a carbapenem was associated with a lower incidence of AKI.