Bactericidal and antibiotic-modulation activities of methanol crude extracts of Ligustrum lucidum and Lobelia inflata against MRSA phenotypes: Molecular docking studies of some isolated compounds from both plants against DNA gyrase A

•The herbal extracts showed weak antibacterial activity against the MRSA strains having MIC > 512 µg/mL.•The combined extracts with standard antibiotics was synergistic (2–64 fold potentiation) and bactericidal (≤ 3log10 CFU/mL).•LILE inhibited PKM 101 only by 30% but strongly against TP114 (74%), whilst LLFE was inactive to both plasmids.•The chromatogram peaks showed that both extracts contain rutin and gallic acid at 330 nm.•LLFE displayed a toxic effect towards HepG2 cells whilst LILE acted non-toxic.•Molecular docking of lobelanidine was the most safer and potent inhibitor of DNA‐gyrase A of Staphylococcus aureus.