Short and long-term results of surgical treatment of non-colorectal liver metastases

Background: Surgical treatment of CRC liver metastases has become the treatment of choice. This has led in recent years to expand surgical indications in metastases from other sources. Methods: 2010-2015: 158 pts with LM (6 non-CRC tumor origin). Analyze surgical technique, morbidity, mortality, long-term results and do a univariate analysis of risk factors and Kaplan-Meier survival. Results: Tumor origin: 3 NET, 2 ovarian, 2 breast, 3 sarcomas, 3 renal, 1 small bowell carcinoma, 1 carcinoid, 1 GIST. 1 second resection, 1 preoperative portal embolization. Resection: 1 not resectable due dissemination, 8 major hepatectomy (50%; 6 right hepatectomies, 1 left hepatectomy and 1 left lateral segmentectomy) and 7 atypical resections. 25% Operative transfusion. 4 patients (28.6%) morbidity, surgical (21.4%), but no patient required reintervention or mortality. Dindo-Clavien: 1 patient grade 2 and 3 grade 3a (21%). Mean stay: 9±5.5 days. With a mean follow-up of 23.7±16 months, 33,3% recurrence (5pts): 1 hepatic, 2 multiple, 1 mediastinal, 1osseous; with an mean SLE of 22.3±17.1 months and SLE at 1 and 3 years of 77.3 and 57.3%, respectively. Major hepatectomy, transfusion, male, age and tumor size were significant related with recurrence. Renal origin recur 100% and 50% of ovarian tumors but without significance. Conclusion: Surgery of patients with non-CRC LM is a good treatment option, with low morbidity and mortality and 3-y DFS close to 60%. The worst result were obtained with tumors of renal or ovarian origin.