Leishmanicidal activity of ibuprofen and its complexes with Ni(II), Mn(II) and Pd(II)

Laís Cardoso Cunha,Daniela Pagliara Lage,Lorena Sales Ferreira,Leonardo Saboia-Vahia,Eduardo Antonio Ferraz Coelho,Vinícius Silva Belo,Rafael Gonçalves Teixeira-Neto,Luis Fernando Soares,Rafael César Russo Chagas,Eduardo Sergio da Silva

Inorganic Chemistry Communications（2020）

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摘要

•The coordination compounds IbuNi, IbuMn and IbuPd were coordinated through the oxygen atom of the deprotonated carboxylate.•IbuNi presented the highest index of selectivity.•IbuNi and IbuMn were able to reduce the infectivity.•IbuPd showed to be toxic.

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关键词

Leishmaniasis,Coordination compounds,Leishmanicidal activity

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