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Eccrine porocarcinoma: A rare case of an in situ tumor with lymph node metastases

JAAD Case Reports(2020)

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Abstract
Eccrine porocarcinoma (EPC) is a rare skin malignancy that represents around 0.01% of all skin tumors.1,2 There is a wide range of clinical presentations of this neoplasm such as papules, plaques, and nodules. Most tumors appear in the head and neck region or on the lower extremities, but all body parts can be involved. EPC is frequently clinically misdiagnosed as squamous cell carcinoma or Bowen disease because the tumors have similar clinical presentations. Therefore, histopathologic examination prior to therapy is required. EPC is known for its high recurrence and metastatic rate of both 20%. Metastases are mostly found in the regional lymph nodes and mortality among patients with EPC with nodal metastasis is high (67%). The survival period for patients with distant metastasis is reported to be 5 to 24 months.1 At this moment, no therapy exists as the gold standard because of the rarity of the disease, although surgery (wide local excision or Mohs micrographic surgery) is the common treatment for local disease. In case of metastatic and/or recurrent disease, it is suggested to add chemotherapy and/or radiotherapy. There is no consistency about which chemotherapy should be added due to the rarity of the disease.1,2 Here we present a patient with EPC in situ with lymph node metastases.
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Key words
Eccrine porocarcinoma,in situ,metastasis,molecular analysis
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