Modified Glutamatergic Postsynapse in Neurodegenerative Disorders

Bruno José Moraes,Patrícia Coelho,Lígia Fão,Ildete Luísa Ferreira,A. Cristina Rego

Neuroscience（2021）

Cited 13|Views3

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Abstract

•The postsynaptic density architecture is complex and dynamic.•In Huntington’s disease, mutant huntingtin affects glutamatergic cortico-striatal synapse function.•In Parkinson’s disease, striatal DA loss impairs postsynaptic morphology and function.•In Alzheimer’s disease, oligomers of amyloid-beta peptide destabilize postsynaptic sites.

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Key words

AD,α7nAChRs,ApoE4,AMPA,AMPARs,Aβ,APP,BDNF,CAG,CIQ,CREB,CaMKII,CNS,DA,D1R,ER,ERK,HD,IP3Rs,JNK,L-DOPA,LIMK,LTD,LTP,mGluRs,MSNs,MAGUKs,MAPK,MPTP,NMDA,NMDARs,6-OHDA,PD,PDZ,PICK1,PS1,PSD,ROCK,RyRs,SER,Shank,STEP,STN,SynGAP,TARPs,VGCCs

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