2-Deoxy-D-Glucose And Its Analogs: From Diagnostic To Therapeutic Agents

B. Pajak, E. Siwiak, M. Soltyka, A. Priebe, R. Zielinski, I. Fokt, M. Ziemniak, A. Jaskiewicz, R. Borowski, T. Domoradzki, W. Priebe

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2020)

Cited 239|Views28
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Abstract
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death. In addition to glycolysis inhibition, other molecular processes are also affected by 2-DG. Attempts to improve 2-DG's drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2-DG analogs as promising new anticancer agents are discussed in this review.
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Key words
2-deoxy-d-glucose,2-DG analogs,glioblastoma,anticancer therapy
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