Epigenetics in Cardiac Hypertrophy and Heart Failure

•Epigenetic mechanisms associated with the pathological process of cardiac hypertrophy and failure include DNA methylation, post-modification of histones, ATP-dependent chromatin conformation and remodeling, and non-coding RNAs.•Systemic- and cardiac-epigenetic mechanisms may both influence the disease processes of cardiac hypertrophy and failure.•Identifying vital epigenetic machinery in cardiac diseases may facilitate developing personalized therapy for HF.