Measurement Of Thrombolysis Enhanced By Ekosonic Catheter-Based Endovascular Therapy
2019 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)(2019)
Abstract
To date, there have been no studies that use ultrasound imaging tools to measure the spatial extent of thrombolysis from catheter-based treatments. This study uses contrast-enhanced ultrasound imaging to measure and visualize plasma clot lysis by either an EkoSonic endovascular system or a conventional side-hole drug delivery catheter. Ultrasound enhances drug-mediated thrombolytic therapy by 80-350%; the degree of enhancement depends on the drug delivery strategy, and the presence or absence of plasma flow through the system during therapy. The measurements and visualizations give a more detailed picture of the lysis process and may inform future strategies for ultrasound-assisted catheter-based intervention.
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Key words
thrombolysis, catheter, ultrasound, clot, imaging
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