PRS68 A RETROSPECTIVE DATABASE STUDY OF A CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENT COHORT TO EVALUATE THE PATIENT CHARACTERISTICS AND ECONOMIC BURDEN OF ILLNESS IN ENGLAND

To define a chronic thromboembolic pulmonary hypertension (CTEPH) cohort of patients and calculate its economic burden from the Hospital Episode statistics (HES) database. A CTEPH patient cohort was defined as a patient having >1 pulmonary embolism ICD-10 code (I26) and >1 pulmonary hypertension (PH) ICD-10 code (I27.0 or I27.9). Prevalent patients were those identified as alive on the 31st of December of each calendar year for the duration of the study period (01/10/2012-31/03/2018). Associated costs were calculated for Accident & Emergency (A&E), inpatient, and outpatient services. A total of 2,152 CTEPH prevalent patients were identified on the 31st December 2017 which compares well to the 2,058 prevalent patients reported for the 31st March 2017 in the 8th National PH Audit. Gender distribution of the cohort was 55.2% female and 44.8% male, with the mean age at first event being 66.4 years (SD = 15.7 years). Both the gender and age at index date remained constant over 5 years. These patient characteristics were comparable to literature values. The total mean cost per prevalent patient in 2017 was £6,746 of which £5,639 (SD=£12,430), 83.6% was for inpatient admissions, £844 (SD=£1,015), 12.5% for outpatient visits and £263 (SD=£1,028), 3.9% for A&E. The annual mean economic burden per CTEPH patients in England (£6,745.04; 2017) was lower in comparison to the US (£58,559; 2012) but higher than that reported for other European countries (£3,977; 2014). The algorithm identified a CTEPH population comparable with literature values and for the first time an economic burden for CTEPH patients in England has been calculated. The high costs associated with inpatient admissions, specifically the cost of managing CTEPH related events, is higher than outpatient visits or A&E attendances.