Prion-like properties of assembled TDP-43.
Current Opinion in Neurobiology(2020)
摘要
•Abnormal TDP-43 aggregates have prion-like properties.•Insoluble TDP-43 accumulated in neuronal cells is propagated to other cells and Serves as seeds for further TDP-43 aggregation in them.•Suppression of propagation of pathological aggregates may be a therapeutic strategy for common neurodegenerative diseases.
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