GIP receptor: Expression in neuroendocrine tumours, internalization, signalling from endosomes and structure-function relationship studies

Jean Claude Reubi,Daniel Fourmy,Arnau Cordomi,Irina G. Tikhonova,Véronique Gigoux

Peptides（2020）

引用 3|浏览17

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摘要

•GIP receptor is expressed in neuroendocrine tumours with high incidence and density•GIP receptor rapidly and abundantly internalizes upon GIP stimulation•Internalized GIP receptor continues to stimulate production of cyclic AMP from early endosomes•Amino acids involved in either ligand binding, receptor activation, G protein binding, or both are identified.

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关键词

GIP,Receptor,Neuroendocrine tumours,Internalization,Signaling,Binding site,Activation mechanism

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