Synthesis and structural characterizations of novel atropoisomeric ferrocene-containing six-membered cyclic ureas

Inspired by an interesting biological/medical features of six-membered cyclic ureas and the characteristic of “atropoisomers – things that rotate”, herein we present an easy performable synthesis of novel atropoisomeric 1-aryl-4-ferrocenyl-3-phenyltetrahydropyrimidin-2(1H)-ones. In addition, the spectral characteristics will be discussed in detail, as well as, the results of single X-ray analyses for separated atropisomers of the same compound.