Selective amides extraction and biological activity from Piper hispidum leaves using the supercritical extraction

•Extraction of Piper hispidum dried leaves was conducted with supercritical CO2 and co-solvents addition.•The use of 5 % of co-solvent increased up to 47 % the extract yield compared to only CO2.•Four cinnamoyl pyrrolidine amides were isolated from SC−CO2 extracts.•The cinnamoyl pyrrolidine amides (up to 74.11 %) were the major compounds identified at supercritical extracts.