Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis

Lei Ma,Guanying Bianca Xu,Xinyu Tang,Cheng Zhang,Wen Zhao,Jie Wang,Hong Chen

Journal of Functional Foods（2020）

Cited 46|Views8

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Abstract

•HPS inhibited proliferation of HCT116 cells significantly.•HPS induced cell cycle arrest in the S and G2/M phases, and increased apoptosis.•HPS down-regulated the AKT pathway by decreasing phosphor-AKT.•HPS induced MAPK pathway by increasing phosphor-p38.

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Key words

Homogeneous polysaccharide,Colon cancer,Cell cycle,Proliferation,Phospho-AKT,MAPK,Hawthorn polysaccharide,Apoptosis

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