Effectiveness of platelet rich plasma injections for non-surgical management of carpal tunnel syndrome: a systematic review and meta-analysis of randomized controlled trials

•Platelet-rich plasma (PRP) is theorized to reduce inflammation and promote neuronal and axon regeneration.•Four randomized controlled trials assessed the effects of PRP on pain and function in carpal tunnel syndrome.•PRP results in significant improvement in the Boston Carpal Tunnel Questionnaire but no change in the visual analog scale.•PRP represents a promising intervention; however, studies were of short follow-up.•Further investigation is necessary to determine the true efficacy and effect of PRP.